Open Access Research article

A novel panel of biomarkers in distinction of small well-differentiated HCC from dysplastic nodules and outcome values

Guang-Zhi Jin1, Hui Dong1, Wen-Long Yu2, Yan Li3, Xin-Yuan Lu1, Hua Yu1, Zhi-Hong Xian1, Wei Dong1, Yin-Kun Liu3*, Wen-Ming Cong1* and Meng-Chao Wu4

Author Affiliations

1 Department of Pathology, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, 200438, China

2 Department II of billiary tract Surgery, Eastern Hepatobiliary Hospital, Second Military Medical University, Shanghai, 200438, China

3 Liver Cancer Institute, Zhong Shan Hospital & Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, China

4 Department of Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, 200438, China

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BMC Cancer 2013, 13:161  doi:10.1186/1471-2407-13-161

Published: 27 March 2013

Additional files

Additional file 1: Table S1:

Clinico-pathological features of the present series. Table S2. Resulted diagnostic models. Table S3. Histological diagnosis and diagnostic model diagnoses of the 45 nodules. Table S4. Chi-Square analysis of factors associated with HGDN and WDHCC. Table S5. Comparison of parameters in GPC3 related OS analyses among several study. Figure S1. Kaplan–Meier curves of survival differences among HCC patients. ACY1. Figure S2. Immunohistochemical expression of ACY1 (A), SQSTM1 (B), and GPC3 (C) in HCC which were divided into ≤2cm and 2cm< and ≤3cm. Integrated Optical Density (IOD) for each marker were obtained from the tissue microarrays. Mann-Whitney Test showed that no significant difference between two groups Table S6. Relationship between glypican-3 expression and clinicopathologic-features of HCC patients in prognosis group. (PDF 343 kb)

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