HP1γ expression in human prostate cancer is increased compared to benign normal prostate tissue. Tissue microarrays (336 cores) containing benign (A and B), HGPIN, low grade (C), high grade (D) and metastatic PCa were immunoflourescently stained for HP1γ (red). E-cadherin (green) labels epithelial cells and DAPI (blue) the cell nuclei. Increased staining is noted in PCa samples with nuclear expression greater than cytoplasmic. Low levels of HP1γ expression were infrequently observed in benign epithelial cells. In contrast, HP1γ was uniformly upregulated in the majority of prostate cancer cells.
Slezak et al. BMC Cancer 2013 13:148 doi:10.1186/1471-2407-13-148