Open Access Research article

Transcriptional effects of 1,25 dihydroxyvitamin D3 physiological and supra-physiological concentrations in breast cancer organotypic culture

Cintia Milani1, Maria Lucia Hirata Katayama1, Eduardo Carneiro de Lyra12, JoEllen Welsh3, Laura Tojeiro Campos1, M Mitzi Brentani1, Maria do Socorro Maciel4, Rosimeire Aparecida Roela1, Paulo Roberto del Valle1, João Carlos Guedes Sampaio Góes2, Suely Nonogaki5, Rodrigo Esaki Tamura6 and Maria Aparecida Azevedo Koike Folgueira1*

Author Affiliations

1 Disciplina de Oncologia, LIM24, Departamento de Radiologia e Oncologia, Faculdade de Medicina da Universidade de São Paulo, Av. Dr. Arnaldo 455,Sala 4124, São Paulo, SP, 01246-903, Brazil

2 Instituto Brasileiro de Controle do Câncer, IBCC, São Paulo, Brazil

3 Department of Environmental Health Sciences, School of Public Health, University at Albany, Rensselaer, NY, 12144, USA

4 Hospital do Câncer A. C. Camargo, São Paulo, Brazil

5 Instituto Adolfo Lutz, Centro de Patologia, Núcleo de Patologia Quantitativa, São Paulo, Brazil

6 Post-doctoral fellow, Viral Vectors Laboratory, Instituto do Câncer do Estado de São Paulo, ICESP, São Paulo, Brazil

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BMC Cancer 2013, 13:119  doi:10.1186/1471-2407-13-119

Published: 15 March 2013

Additional files

Additional file 1: Table S1:

Primers.

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Additional file 2: Table S2:

Gene sets enriched in breast tumor slices incubated in 0.5nM 1,25(OH)2D3.

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Additional file 3: Table S3:

Genes differentially modulated in breast tumor slices incubated in 100 nM 1,25(OH)2D3.

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Additional file 4:

Unsupervised hierarchical clustering of breast cancer tissue slices exposed to vehicle or 1,25(OH)2D3 100 nM.

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Additional file 5: Table 4:

Correlation of gene expression values (microarray vs qPCR) evaluated in breast cancer slices.

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