Effects of the combination of doranidazole and X-irradiation on tumor hypoxia in C6 glioma. Histological evaluation of C6 tumors at 1 day after treatment. (A) Immunohistochemical images for pimonidazole. Animals received vehicle (a), doranidazole (200 mg/kg) (b), 6 Gy of X-rays (c), or a combination (d) as described in Figure 4. A representative field for each condition is shown. Bar = 500 μm. (B) Representative images of pimonidazole staining and H/E staining taken at high magnification in C6 tumors resected from the control group (a) and the combination group (b). Bar = 100 μm.
Yasui et al. BMC Cancer 2013 13:106 doi:10.1186/1471-2407-13-106