Disruption of the BBB in the brain of a C6-bearing rat. (A) Representative photographs of the dorsal surface (I), ventral surface (II), coronal slice (III) and sagittal slice (IV) of control brain (a) and C6-bearing brain (b) after perfusion with Evans blue dye. (B) Representative T1-weighted MR images obtained before and after Gd-[DTPA] injection. White lines show the region with high signal intensity, indicating the BBB-disrupted region. (C) Quantitative data for Gd-[DTPA]-based CE-MRI. Relative MRI signal intensities are expressed as ratios relative to the normal brain region.
Yasui et al. BMC Cancer 2013 13:106 doi:10.1186/1471-2407-13-106