Table 1

Clinical, demographic and laboratorial features of T-ALL patients according to NOTCH1 status, 2001-2008

Variable

n (%)

NOTCH1 mut n (%)

NOTCH1 wt n (%)

p value


Age (Years)

< 10

71 (51.4)

28 (46.7)

43 (55.1)

0.324

10-18

67 (48.6)

32 (53.3)

35 (44.9)

Gender

Male

100 (72.5)

46 (76.7)

54 (69.2)

0. 332

Female

38 (27.5)

14 (23.3)

24 (30.8)

WBC (×109/L)

<50

63 (45.7)

29 (48.3)

34 (43.6)

0.579

≥50

75 (54.3)

31 (51.7)

44 (56.4)

Mediastinal massa

Yes

58 (44.6)

24 (42.9)

34 (45.9)

0.726

No

72 (55.4)

32 (57.1)

40 (54.1)

Skin colour

White

60 (43.5)

21 (35.0)

39 (50.0)

0.078

Non-white

78 (56.5)

39 (65.0)

39 (50.0)

T-ALL subtypesb

T-I

18 (13.8)

9 (15.5)

9 (12.5)

0.343

T-II

29 (22.3)

9 (15.5)

20 (27.8)

T-III

34 (26.2)

18 (31.0)

16 (22.2)

T-IV

49 (37.7)

22 (37.9)

27 (37.5)

CD10 statusc

positive

36 (31.0)

16 (30.2)

20 (31.7)

0.857

negative

80 (69.0)

37 (69.8)

43 (68.3)

Molecular Studies

SIL-TAL1 pos

37 (28.7)

19 (32.8)

18 (25.4)

0.355

HOX11L2 pos

10 (8.4)

6 (11.1)

4 (6.2)

0.332

FBXW7 mut

21 (19.1)

13 (24.1)

8 (14.3)

0.192

KRAS mut

10 (9.5)

4 (7.7)

6 (11.3)

0.527

PTEN mut

9 (9.4)

5 (10.9)

4 (8.0)

0.630


Total

138 (100)

60 (100)

78 (100)


Mansur et al. BMC Cancer 2012 12:9   doi:10.1186/1471-2407-12-9

Open Data