Open Access Research article

Impact of complex NOTCH1 mutations on survival in paediatric T-cell leukaemia

Marcela Braga Mansur1, Rocio Hassan2, Thayana C Barbosa1, Alessandra Splendore3, Patricia Y Jotta4, José Andrés Yunes4, Joseph L Wiemels5 and Maria S Pombo-de-Oliveira16*

Author Affiliations

1 Paediatric Haematology-Oncology Program, Research Centre, Instituto Nacional de Câncer, Rio de Janeiro, RJ, Brazil

2 Bone Marrow Transplantation Centre (CEMO), Instituto Nacional de Câncer, Rio de Janeiro, RJ, Brazil

3 Human Genome Studies Center, Instituto de Biociências, Universidade de São Paulo, São Paulo, SP, Brazil

4 Molecular Biology Laboratory, Centro Infantil Boldrini, Campinas, SP, Brazil

5 Laboratory for Molecular Epidemiology, Department of Epidemiology & Biostatistics, University of California, San Francisco, CA, USA

6 Paediatric Haematology-Oncology Program, 6th floor, Research, Center, Instituto Nacional de Câncer-MS, Rua André Cavalcanti, 37, 20231-050 Rio de Janeiro, RJ, Brazil

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BMC Cancer 2012, 12:9  doi:10.1186/1471-2407-12-9

Published: 6 January 2012

Additional files

Additional file 1:

Table S1. Detailed descriptions of all NOTCH1 mutations sequences according to domain involved.

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Additional file 2:

Figure S1. Kaplan-Meier overall survival curves for T-ALL patients. (A) Overall survival (OS) according to the presence of KRAS mutations. One hundred and five cases were included in this analysis, 10 with KRAS mutated and 95 WT. (B) OS according to the presence of PTEN mutations. In the PTEN OS analysis were included 96 patients, being 9 with mutations and 87 WT. (C) OS according to the expression of the TLX3 gene. For the construction of this OS curve, 119T-ALL cases were analyzed, 10 TLX3+ and 109 TLX3-(D) OS of patients treated with GBTLI (Brazilian Group for Treatment of Childhood Leukaemia) therapeutic protocol compared with ALL-BFM (Berlin-Frankfurt-Munster) protocols backbone strategies. Symbols represent censored cases. All 138 cases were included for Treatment Protocol OS analysis, 101 treated according GBTLI and 37 according BFM.

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