Additional file 5.

Figure S4 Copy number analysis of CTCs versus matched archival primary tumor in two patients. (A) 20 CTCs from patient #17 and a corresponding archival primary tumor from local extension to the bladder obtained 1 year and 3 months prior to CTC analysis; and (B) 18 CTCs from patient #20 and a matched primary tumor obtained 5 years and 1 month prior to CTC analysis. For each case, the top panel shows frequency of genomic aberrations [gains (green) and losses (red)] between the paired samples such that chromosomal aberrations with frequency equal to 100% have been gained and lost in both CTCs and archival primary tumor. The lower panel shows output of segmentation analysis providing high confidence copy number calls for each sample.

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Magbanua et al. BMC Cancer 2012 12:78   doi:10.1186/1471-2407-12-78