Effect of BRMS1 on migration and invasion of melanoma cells. BRMS1 expression was transiently down-regulated using siRNA in the metastatic melanoma cell lines WM239 and FEMX-1 (A) and analyzed for migration and invasion ability in a transwell chamber assay (B). Bars represent mean ratio of cells ± SE of cells in the lower compartment compared to total number of cells in both compartments from at least three independent biological experiments. WM239: invasion; p = 0.047, migration; p = 0.013, FEMX-1; invasion; p = 0.016, migration; p = 0.43.
Slipicevic et al. BMC Cancer 2012 12:73 doi:10.1186/1471-2407-12-73