Table 4

Sensitivity and specificity within the ≥ 5%, ≥ 10%, ≥ 20% and ≥ 30% thresholds of the risk prediction models for the MMR germline mutation

Models and threshold

Sensitivity

Specificity


MMRpro

≥ 5%

1.00

0.03

≥ 10%

0.96

0.08

≥ 20%

0.90

0.38

≥ 30%

0.87

0.52

MMRPredict

≥ 5%

0.93

0.38

≥ 10%

0.90

0.33

≥ 20%

0.83

0.70

≥ 30%

0.80

0.75

Myriad

≥ 5%

1.00

0

≥ 10%

0.94

0.31

≥ 20%

0.74

0.56

≥ 30%

0.10

0.92

PREMM

≥ 5%

0.98

0.28

≥ 10%

0.90

0.54

≥ 20%

0.67

0.85

≥ 30%

0.67

0.85

Wijnen

≥ 5%

1.00

0

≥ 10%

0.94

0.31

≥ 20%

0.74

0.56

≥ 30%

0.10

0.92


Monteiro Santos et al. BMC Cancer 2012 12:64   doi:10.1186/1471-2407-12-64

Open Data