Table 1

Correlations between HuR and cyclin A expression and other important clinicopathological parameters
Parameter No. of cases HuR Cyto. Exp. pvalue Cyclin A Exp. pvalue
Low High Low High
Gender Male 182 93 89 0.664 85 95 0.384
Female 158 77 81 83 75
Age (years) <65 138 72 66 0.508 75 63 0.185
≥65 202 98 104 95 107
Tumor side Right 177 96 81 0.201 89 88 0.931
Left 154 71 83 76 78
Bilateral 9 3 6 5 4
Tumor location Renal pelvis 141 76 65 0.374 66 75 0.607
Ureter 150 73 77 78 72
Renal pelvis and ureter 49 21 28 26 23
Multifocality Single 278 143 135 0.261 140 138 0.779
Multifocal 62 27 35 30 32
Primary tumor (T) Ta ~ T1 181 109 72 <0.001* 104 77 0.003*
T2 ~ T4 159 61 98 66 93
Nodal metastasis Negative (N0) 312 166 146 <0.001* 159 153 0.237
Positive (N1 ~ N2) 28 4 24 11 17
Histological grade Low grade 56 37 19 0.008* 39 17 0.001*
High grade 284 133 151 131 151
Pattern of invasion Non-invasive/Nodular 200 112 88 0.030* 108 92 0.191
Trabecular 58 24 34 27 31
Infiltrative 82 34 48 35 47
Vascular invasion Absent 234 126 108 0.035* 124 110 0.101
Present 106 44 62 46 60
Perineurial invasion Absent 321 166 155 0.009* 162 159 0.479
Present 19 4 15 8 11
Mitotic rate (per 10 high power fields) <10 173 89 84 0.588 103 70 <0.001*
≥10 167 81 86 67 100
Cyclin A expression Low 164 95 69 0.005* - - -
High 176 75 101 - -

Cyto. Exp., cytoplasmic expression. * Statistically significant.

Liang et al.

Liang et al. BMC Cancer 2012 12:611   doi:10.1186/1471-2407-12-611

Open Data