Table 1

Study flow-chart (per chemotherapy cycle)
Day-1 Day 1 Day 2 Day3 Day4 Day 5 Day 6
Tablets of Cocculine or placebo Evening Morning Noon Evening Morning Noon Evening Morning
Antiemetic treatment 2 2 2 2 2 2
Chemotherapy P1 (TAC) S2 + M3 S4 + P1 S4 + P1 S4 + P1 S4 + P1
Phone call X* X X**
FLIE questionnaire
Patients diary X
X X X X X

Po: per os; IV: intraverious; P: Prednisolone; M: Methyprednisolone; S: Ondansetron.

1: 60 mg po (TAC only); 2: 8 mg IV; 3: 60mg IV; 4: 8 mg po; *: all patients; **: on patients’ request.

Pérol et al.

Pérol et al. BMC Cancer 2012 12:603   doi:10.1186/1471-2407-12-603

Open Data