Table 2

Serum testosterone by androgen and estrogen receptor expression in natural postmenopausal women with breast cancer
Testosterone
No. % Mean ± SD (ng/ml) P
All natural menopause
 AR expression
  Absent 59 13.1 0.434 ± 0.198 0.099b 0.002c 0.002d
  Poor 111 24.7 0.385 ± 0.187
  Moderate 120 26.8 0.384 ± 0.166
  High 159 35.4 0.462 ± 0.215
  Totala 449 100.0 0.419 ± 0.196
ER-positive
 AR expression
  Absent 31 8.2 0.451 ± 0.203 0.116b 0.003c 0.022d,f 0.216e,f
  Poor 91 24.1 0.402 ± 0.189
  Moderate 107 28.3 0.385 ± 0.170
  High 149 39.4 0.470 ± 0.217
  Total 378 100.0 0.428 ± 0.200g
ER-negative
 AR expression
  Absent 28 39.4 0.415 ± 0.193 0.510b 0.204c
  Poor 20 28.2 0.310 ± 0.160
  Moderate 13 18.3 0.378 ± 0.124
  High 10 14.1 0.345 ± 0.139
  Total 71 100.0 0.369 ± 0.168g

NOTES. Androgen receptor (AR) expression: absent, 0%; poor, ≥1 to 30%; moderate, >30 to 60%; high, >60%. Estrogen receptor (ER)-positive : ER expression ≥10%.

aTwo women had missing information on ER status. bTest for linear trend. cFisher’s test. dLinear contrast comparing AR-high to AR-absent, AR-low and AR-moderate combined. eLinear contrast comparing AR-absent to AR-low and AR-moderate combined. fBonferroni adjusted P value. gFisher’s test P=0.023.

Secreto et al.

Secreto et al. BMC Cancer 2012 12:599   doi:10.1186/1471-2407-12-599

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