Research article
Association of p21 SNPs and risk of cervical cancer among Chinese women
Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China
BMC Cancer 2012, 12:589 doi:10.1186/1471-2407-12-589
Published: 11 December 2012Additional files
Additional file 1:
Table S1. Methods used for p21 SNP genotyping.
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Additional file 2:
Figure S1. Sample sequence tracing of rs762623 and rs2395655 SNPs showing homozygosity for each allele (top and bottom) or heterozygosity (middle).
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Additional file 3:
Figure S2. PCR-RFLP analysis of p21 SNP rs1801270A/C. The 310 bp PCR products were digested by BglI, and presence of the C allele resulted in two bands of sizes 239 and 71 bp. Electrophoresis was performed in 3% agarose gel.
Format: TIFF Size: 184KB Download file
Additional file 4:
Figure 3. PCR-RFLP analysis of p21 SNP rs3176352A/C. The 448 bp PCR products were digested by ApaLI, and presence of the C allele resulted in two bands of sizes 289 and 159 bp. Electrophoresis was performed in 2.5% agarose gel.
Format: TIFF Size: 51KB Download file
Additional file 5:
Figure S4. PCR-RFLP analysis of p21 SNP rs1059234T/C. The 480 bp PCR products were digested by PstI, and presence of the C allele resulted in two bands of sizes 291 and 189 bp. Electrophoresis was performed in 2.5% agarose gel. (TIFF 571 kb)
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Additional file 6:
Table S2. Pairwise linkage disequilibrium analysis for all five p21 SNPs for all subjects studied.
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