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Open Access Research article

Association of p21 SNPs and risk of cervical cancer among Chinese women

Ning Wang, Shizhuo Wang, Qiao Zhang, Yanming Lu, Heng Wei, Wei Li, Shulan Zhang*, Duo Yin and Yangling Ou

Author Affiliations

Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China

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BMC Cancer 2012, 12:589  doi:10.1186/1471-2407-12-589

Published: 11 December 2012

Additional files

Additional file 1:

Table S1. Methods used for p21 SNP genotyping.

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Additional file 2:

Figure S1. Sample sequence tracing of rs762623 and rs2395655 SNPs showing homozygosity for each allele (top and bottom) or heterozygosity (middle).

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Additional file 3:

Figure S2. PCR-RFLP analysis of p21 SNP rs1801270A/C. The 310 bp PCR products were digested by BglI, and presence of the C allele resulted in two bands of sizes 239 and 71 bp. Electrophoresis was performed in 3% agarose gel.

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Additional file 4:

Figure 3. PCR-RFLP analysis of p21 SNP rs3176352A/C. The 448 bp PCR products were digested by ApaLI, and presence of the C allele resulted in two bands of sizes 289 and 159 bp. Electrophoresis was performed in 2.5% agarose gel.

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Additional file 5:

Figure S4. PCR-RFLP analysis of p21 SNP rs1059234T/C. The 480 bp PCR products were digested by PstI, and presence of the C allele resulted in two bands of sizes 291 and 189 bp. Electrophoresis was performed in 2.5% agarose gel. (TIFF 571 kb)

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Additional file 6:

Table S2. Pairwise linkage disequilibrium analysis for all five p21 SNPs for all subjects studied.

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