Efficacy of psychodynamic short-term psychotherapy for depressed breast cancer patients: study protocol for a randomized controlled trial
- Equal contributors
1 Department for Psychosomatic Medicine and Psychotherapy, University Medical Center Mainz, Untere Zahlbacher Str. 8, 55131, Mainz, Germany
2 Interdisciplinary Center for Clinical Trials, University Medical Center Mainz, Langenbeckstr., 2, 55131, Mainz, Germany
3 Clinic for Radiotherapy, University Medical Center Mainz, Langenbeckstr., 2, 55131, Mainz, Germany
4 St. Josefs-Hospital, Breast Center, Beethovenstr., 20, 65189, Wiesbaden, Germany
5 Clinic for Gynecology, Breast Center, University Medical Center Mainz, Langenbeckstr., 2, 55131, Mainz, Germany
6 St. Georg-Hospital, Breast Center, Delitzscher Str. 141, 04129, Leipzig, Germany
7 St. Elisabeth Hospital, Breast Center, Biedermannstr., 84, 04277, Leipzig, Germany
8 Clinic for radiotherapy, University Medical Center Leipzig, Stephanstr., 9, 04103, Leipzig, Germany
9 Department for Medical Psychology and Medical Sociology, University Leipzig, Philipp-Rosenthal-Str. 55, 04103, Leipzig, Germany
BMC Cancer 2012, 12:578 doi:10.1186/1471-2407-12-578Published: 5 December 2012
There is a lack of psychotherapeutic trials of treatments of comorbid depression in cancer patients. Our study determines the efficacy of a manualized short-term psychodynamic psychotherapy and predictors of outcome by personality and quality of the therapeutic relationship.
Eligible breast cancer patients with comorbid depression are assigned to short-term psychodynamic psychotherapy (up to 20 + 5 sessions) or to treatment as usual (augmented by recommendation for counseling center and physician information). We plan to recruit a total of 180 patients (90 per arm) in two centers. Assessments are conducted pretreatment, after 6 (treatment termination) and 12 months (follow-up). The primary outcome measures are reduction of the depression score in the Hospital Anxiety and Depression Scale and remission of depression as assessed by means of the Structured Clinical Interview for DSM IV Disorders by independent, blinded assessors at treatment termination. Secondary outcomes refer to quality of life.
We investigate the efficacy of short-term psychodynamic psychotherapy in acute care and we aim to identify predictors for acceptance and success of treatment.