Table 3

Univariate and multivariate analysis of overall survival by Cox model in gastric cancer
Variable Univariate cox Multivariate cox
HR 95% CI P HR 95% CI P
Sex: female vs male 0.896 0.728-1.103 0.302
Age, years: ≤40 vs ≤50 vs ≤65 vs >65 1.262 1.127-1.412 <0.001 1.226 1.089-1.379 0.001
Tumor site: upper vs middle vs lower vs diffuse† 0.998 0.883-1.128 0.976
Tumor size, cm: ≤2 vs ≤3 vs ≤5 vs >5 1.590 1.434-1.764 <0.001 1.149 1.023-1.291 0.019
Tumor grade: well vs moderate vs poor 1.540 1.287-1.841 <0.001 1.191 0.959-1.481 0.114
Lauren type: intestinal vs diffuse vs mixed 1.202 1.020-1.415 0.028 1.143 0.945-1.383 0.167
T classification: pT1 vs pT2 vs pT3 vs pT4‡ 2.135 1.859-2.451 <0.001 1.490 1.263-1.757 <0.001
N classification: pN0 vs pN1 vs pN2 vs pN3‡ 2.237 2.017-2.481 <0.001 1.733 1.543-1.947 <0.001
Radical resection: yes vs no 3.337 2.706-4.114 <0.001 2.053 1.641-2.570 <0.001
TNM stage: I vs II vs III vs IVठ2.306 2.064-2.576 <0.001
ERα: positive vs negative 1.990 1.380-2.871 <0.001 1.159 0.797-1.685 0.441
ERβ: positive vs negative 1.107 0.779-1.573 0.572
PR: positive vs negative 0.905 0.723-1.135 0.389
AR: positive vs negative 1.265 1.023-1.564 0.030 1.072 0.858-1.340 0.541

HR, hazard ratio; CI, confidence interval; ERα, estrogen receptor alpha; ERβ, estrogen receptor beta; PR, progesterone receptor; AR, androgen receptor. †Japanese Classification of Gastric Carcinoma (3rd English edition) proposed by the Japanese Gastric Cancer Association (JGCA). ‡The 6th TNM Classification of Malignant Tumors proposed by the AJCC/UICC. §TNM stage was not included into multivariate Cox model to avoid repetition with T and N classifications.

Gan et al.

Gan et al. BMC Cancer 2012 12:566   doi:10.1186/1471-2407-12-566

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