Open Access Highly Accessed Research article

Curcumin and synthetic analogs induce reactive oxygen species and decreases specificity protein (Sp) transcription factors by targeting microRNAs

Shruti U Gandhy1, KyoungHyun Kim2, Lesley Larsen3, Rhonda J Rosengren4 and Stephen Safe25*

Author Affiliations

1 College of Medicine, Texas A&M Health Sciences Center, Houston, TX, 77030, USA

2 Institute of Biosciences and Technology, Texas A&M Health Science Center, 2121 W. Holcombe Blvd, Houston, TX, 77030, USA

3 Department of Chemistry, University of Otago, P.O. Box 56, Dunedin, 9054, New Zealand

4 Department of Pharmacology and Toxicology, University of Otago, P.O. Box 913, Dunedin, 9054, New Zealand

5 Department of Veterinary Physiology and Pharmacology, Texas A&M University, 4466 TAMU, College Station, TX, 77843-4466, USA

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BMC Cancer 2012, 12:564  doi:10.1186/1471-2407-12-564

Published: 30 November 2012

Additional files

Additional file 1:

Figure S1. Effects of RL197 on proliferation of CCD-18Co colon fibroblasts (A) and induction of Annexin V staining by curcumin and RL197 in RKO (B) and SW480 (C) colon cancer cells.

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Additional file 2:

Figure S2. ROS induction by curcumin. RKO cells were treated with 20 or 30 μM curcumin alone or with GSH. ROS was determined 6, 12, 18 or 24 hr after treatment by FACS analysis as outlined in the Materials and Methods.

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