Salinomycin causes a decrease in cell viability and induces apoptosis. (A) MTS assay shows salinomycin causes a selective decrease in cell proliferation of JLO-1 compared to UMSCC-10B. The absorbance values (Y-axis) were normalized by dividing over the absorbance of each control. Error bars represent standard deviation. (B) TUNEL assay shows an increase in apoptosis with a 2 μM salinomycin treatment indicated by the percent increase in DNA strand breaks. (C) Western blot demonstrates a dose dependent increase in apoptosis as seen by the induction in Bax/Bcl-2 ratio.
Kuo et al. BMC Cancer 2012 12:556 doi:10.1186/1471-2407-12-556