DCE-MRI data for CK-160 cervical carcinoma xenografts imaged with gadomelitol as contrast agent. (A) The parametric images of Ktrans, ve, VbTofts, Ki, and VbPatlak of a representative tumor. (B) The Ktrans, ve, VbTofts, Ki, and VbPatlak frequency distributions of the same tumor. (C) Gadomelitol concentration versus time for three representative single voxels of the same tumor. The curves were fitted to the data by using the Tofts pharmacokinetic model. (D) Ct(T)/Ca(T) versus ∫Ca(t)dt/Ca(T) for the same three voxels. The curves were fitted to the data by using the Patlak pharmacokinetic model.
Hompland et al. BMC Cancer 2012 12:544 doi:10.1186/1471-2407-12-544