Table 1

Putative small molecule binding sites in EWS-FLI1 protein
SITE Residue Number Score
4 21,156–167,170,173,176-196,203-207,218- 223 247,248, 317–327, 389, 391, 394,447-450,454,498 1.151
3 109-112,117,120,121,124,125,128,129,146-148,150-153,298 305, 307, 308,310,315,317,324,325,327,328,331,332,335,345,347,380,382,383,385-389, 481-490 1.077
2 12-16,54-64,66-69,81-86,89-98,100-103,105,107,109,112,119 – 124, 127 , 128,132-146,272,276,290,296,311 1.047
6 25,65,71-75,77,209,213-217,236-247,250,254-264,278-286 1.043
5 1,14-16,29,31,32,35,36,41-44,49,50,54-59,66,67,90,92-97,261-264,267-272 1.032
9 150,151,158-160,315,317-329,350,377-380,387-391,456,461,489-492 1.026
1 22,25-34,36-40,163,188,190-211,214,216-218,246-254,257-259, 261,262,264,279-282,318,352,365-369,377,378,391-401,436,439-450,454 1.007
8 179-181,184,206-208,216,219-223,229-237,240,244,246,285,288,289 0.944
7 11,104,106,144-147,307-314,374,383-388,410-413,476,479-482,484 0.948
10 61-63,80-86,89,118,119,223,234,235,288-296 0.777

The table lists the binding sites along with the amino acid residues which form the sites. Residues numbered in bold denote the region in the vicinity of the junction of EWS-FLI1 protein.

Jully et al.

Jully et al. BMC Cancer 2012 12:513   doi:10.1186/1471-2407-12-513

Open Data