Open Access Research article

Increased frequency of single base substitutions in a population of transcripts expressed in cancer cells

Laurent Bianchetti1*, David Kieffer2, Rémi Féderkeil3 and Olivier Poch2

Author Affiliations

1 Plate-forme Bioinformatique de Strasbourg (BIPS), Institut de Génétique et de Biologie Moléculaire et Cellulaire (CNRS/INSERM/ULP), BP 163, Illkirch, Cedex, 67404, France

2 Laboratoire de Bioinformatique et Génomique Intégratives (LBGI), Institut de Génétique et de Biologie Moléculaire et Cellulaire (CNRS/INSERM/ULP), BP 163, Illkirch, Cedex, 67404, France

3 IRMA-UdS, Equipe Statistique, 7 rue René Descartes, Strasbourg, Cedex, 67084, France

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BMC Cancer 2012, 12:509  doi:10.1186/1471-2407-12-509

Published: 8 November 2012

Additional files

Additional file 1:

Generation of 17 distinct patterns for each RT.

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Open Data

Additional file 2:

Risk that a sbsRT matches by chance the RT of a transcript.

Format: PDF Size: 86KB Download file

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Additional file 3:

L-SAGE and Tag-seq experiment sizes (sequencing effort).

Format: XLSX Size: 21KB Download file

Open Data

Additional file 4:

RT with greater SBS frequency in cancer than in healthy cells (L-SAGE).

Format: XLSX Size: 86KB Download file

Open Data

Additional file 5:

RT with greater SBS frequency in cancer than in healthy cells (Tag-seq).

Format: XLSX Size: 712KB Download file

Open Data

Additional file 6:

Manual checking of possible cancer related somatic mutations altering RT with greater SBS frequencies in cancer than in healthy cells (L-SAGE).

Format: PDF Size: 309KB Download file

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Open Data

Additional file 7:

Manual checking of possible cancer related somatic mutations altering RT with greater SBS frequencies in cancer than in healthy cells (Tag-seq).

Format: PDF Size: 1.4MB Download file

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Open Data

Additional file 8:

Manual checking of possible APOBEC1 RNA-editing targets altering RT with greater SBS frequencies in cancer than in healthy cells (L-SAGE).

Format: PDF Size: 258KB Download file

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Open Data

Additional file 9:

Manual checking of possible APOBEC1 RNA-editing targets altering RT with greater SBS frequencies in cancer than in healthy cells (Tag-seq).

Format: PDF Size: 404KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data