Table 6

Association of organic solvent exposure with nasal malignancies
Controls (%) Cases (%) OR (95% CI)
All study participants
Reference* 1815 (75.6) 281 (65.8) 1.0
Ever exposed for at least 1 year§ 586 (24.4) 146 (34.2) 1.56 (1.17–2.01)
Per year of exposure§ 586 (24.4) 146 (34.2) 1.02 (1.01–1.03)
Exposure (tertiles) < 7 years 198 (8.2) 44 (10.3) 1.57 (1.03–2.38)
7 < 20 years 183 (7.6) 37 (8.7) 1.23 (0.77–1.96)
20+ years 205 (8.5) 65 (15.2) 1.75 (1.19–2.58)
Smokers
Reference* 1064 (75.2) 185 (63.4) 1.00
Ever exposed for at least 1 year§ 351 (24.8) 107 (36.6) 1.95 (1.34–2.83)
Per year of exposure§ 351 (24.8) 107 (36.6) 1.02 (1.01–1.04)
Exposure (tertiles) < 7 years 123 (8.7) 31 (10.6) 2.08 (1.19–3.65)
7 < 20 years 116 (8.2) 25 (8.6) 1.45 (0.76–2.77)
20+ years 112 (7.9) 51 (17.5) 2.24 (1.31–3.82)
Never-smokers
Reference* 751 (76.2) 96 (71.1) 1.00
Ever exposed for at least 1 year§ 235 (23.8) 39 (28.9) 1.06 (0.61–1.84)
Per year of exposure§ 235 (23.8) 39 (28.9) 0.99 (0.97–1.02)
Exposure (tertiles) < 7 years 75 (7.6) 13 (9.6) 1.98 (0.84–4.65)
7 < 23 years 80 (8.1) 14 (10.4) 0.61 (0.22–1.67)
23+ years 80 (8.1) 12 (8.9) 0.96 (0.44–2.11)

*never exposed to organic solvents.

§daily/several days per week.

Adjustments: Year of birth, community size, educational attainment, pack-years (all study participants), snuff package-years, years of exposure to hardwood dust, asbestos, use of nasal spray/nasal lavage and ever-use of insecticides in residences.

Greiser et al.

Greiser et al. BMC Cancer 2012 12:506   doi:10.1186/1471-2407-12-506

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