Table 2

Association of nasal snuff and smoking with nasal malignancies
Controls (%) Cases (%) OR (95% CI)
All study participants
Reference* 2273 (94.7) 399 (93.4) 1.00
Nasal snuff (ever) 128 (5.3) 28 (6.6) 1.45 (0.88–2.38)
Nasal snuff package-years§ 128 (5.3) 28 (6.6) 1.01 (1.00–1.02)
Snuff package-years (quartiles) < 2 31 (1.3) 2 (0.5) 0.52 (0.10–2.68)
2 < 4 27 (1.3) 5 (1.2) 1.16 (0.36–3.75)
4 <12.5 37 (1.1) 9 (2.1) 1.29 (0.53–3.12)
12.5+ 33 (1.4) 12 (2.8) 2.41 (1.13–5.15)
Smokers
Reference* 1333 (94.2) 272 (93.2) 1.00
Nasal snuff (ever) 82 (5.8) 20 (6.8) 2.01 (1.00–4.02)
Nasal snuff package-years§ 82 (5.8) 20 (6.8) 1.02 (1.01–1.04)
Snuff package-years(quartiles) < 2 16 (1.1) 1 (0.3) 0.60 (0.04–8.33)
2 < 4 19 (1.3) 3 (1.0) 0.75 (0.11–4.96)
4 <12.5 26 (1.8) 7 (2.4) 1.36 (0.44–4.25)
12.5+ 21 (1.5) 9 (3.1) 6.91 (2.31–2 0.69)
Never-smokers
Reference* 940 (95.3) 127 (94.1) 1.00
Nasal snuff (ever) 46 (4.7) 8 (5.9) 1.10 (0.43–2.80)
Nasal snuff package-years§ 46 (4.7) 8 (5.9) 1.00 (0.98–1.02)

* never used nasal snuff.

§ One package-year = use of 1 package per week for one year.

Adjustments: Year of birth, community size, educational attainment, cigarette packyears (all study participants only), exposure to hardwood dust, asbestos, organic solvents, use of nasal spray/nasal lavage and ever-use of insecticides in homes.

Greiser et al.

Greiser et al. BMC Cancer 2012 12:506   doi:10.1186/1471-2407-12-506

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