Table 4

Treatment outcomes
Characteristic Glutamine (+) Glutamine (−) P-value
(N=56) (N=48)
Maximum grade ARIE (N; %)
0–1 40 (71.4) 21 (43.7) 0.02
2 37.0 34.2
3 27.8 22.8
4 - 5 0 (0) 0 (0)
Grade 2–3 ARIE onset (days)
Median 24.5 16.4 0.001
Range (17 – 32) (9–23)
Treatment delay (N; %) 4 (7.1) 10 (20.8%) 0.04
Hospitalization 2 (3.6) 3 (6.3) 0.14
Weight change (N; %)
No change or gain 31 (55.4) 13 (27.1) 0.002
Loss 25 (44.6) 35 (72.9)
Weight change (kg)
Median 2.6 −3.3 < 0.001
Range (−3.1 to 7.6) (−9.7 to 2.3)
Weight change (%)
Median 3.94 −4.91 < 0.001
Range (−4.7 to 11.5) (−14.4 to 3.4)
LET (maximum grade)
2 2 (3.6) 3 (6.3) 0.06
3 0 (0) 3 (6.3)
4 - 5 0 (0) 0 (0)

Abbreviations:ARIE: Acute radiation-induced esophagitis; LET: Late esophageal toxicity.

Topkan et al.

Topkan et al. BMC Cancer 2012 12:502   doi:10.1186/1471-2407-12-502

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