Open Access Research article

Highly frequent PIK3CA amplification is associated with poor prognosis in gastric cancer

Jing Shi1, Demao Yao2, Wei Liu1, Na Wang1, Hongjun Lv1, Guanjun Zhang3, Meiju Ji1, Li Xu1, Nongyue He4, Bingyin Shi1 and Peng Hou1*

Author Affiliations

1 Department of Endocrinology, The First Affiliated Hospital of Xi'an Jiaotong University School of Medicine, Xi'an 710061, the People's Republic of China

2 Department of Surgery, The First Affiliated Hospital of Xi'an Jiaotong University School of Medicine, Xi'an 710061, the People's Republic of China

3 Department of Pathology, The First Affiliated Hospital of Xi'an Jiaotong University School of Medicine, Xi'an 710061, the People's Republic of China

4 State Key Laboratory of Bioelectronics, Southeast University, Nanjing 210096, the People's Republic of China

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BMC Cancer 2012, 12:50  doi:10.1186/1471-2407-12-50

Published: 1 February 2012

Additional files

Additional file 1:

Figure S1. Somatic mutations identified in the PIK3CA gene in gastric cancers. Examples of somatic mutations found in the helical and kinase domains of PIK3CA. Arrows indicate the position of the missense mutations. The amino acid changes are given above the arrows. Figure S2. Association of PIK3CA mutations and amplification with poor survival in gastric cancer. Kaplan-Meier survival curves was made according to the presence of PIK3CA mutations or amplification in a large cohort of gastric cancers. (A) PIK3CA mutations were not associated with poor survival of the patients. (B) The patients with PIK3CA amplification had a significantly shorter survival than the patients without PIK3CA amplification (P = 0.01). PIK3CA Mu, PIK3CA mutations; PIK3CA Am, PIK3CA amplification; +, harboring PIK3CA mutations or amplification; -, the lack of PIK3CA mutations or amplification. Table S1. PIK3CA mutations and amplification in gastric cancer--univariate associations with clinicopathological features (OR† and 95%CI).

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