Table 4

Fit of the model to the data for the 27 blocks with grouped data
Block: studya Measureb Rangec FEV1%P Diffd RR (95%CI) Fitted RR Cases observede Cases fitted
1: BEATY FEV1%P >80 (95.33) 1.00 1.00 14.30 14.30
β (SE) = −0.028 (0.034) ≤80 29.77 0.43 (0.06-3.20) 0.43 1.03 1.03
2: CALABR FEV1%P 90+ (104.94) 1.00 1.00 24.20 25.71
β (SE) = 0.024 (0.008) 70 to <90 23.90 2.29 (1.24-4.23) 1.76 17.09 13.98
χ2 (df) = 1.04 (1) <70 49.60 2.90 (1.34-6.27) 3.25 8.50 10.11
3: CARETf FEV1%P 80+ (100.75) 1.00 1.00 35.35 34.69
β (SE) = 0.022 (0.007) 70 to <80 24.89 1.54 (0.80-2.63) 1.74 14.59 16.20
χ2 (df) = 0.22 (2) 60 to <70 34.92 2.25 (1.20-4.19) 2.18 12.39 11.77
<60 49.07 3.08 (1.42-6.69) 2.99 6.92 6.59
4: CARETg FEV1%P 80+ (91.97) 1.00 1.00 16.66 15.78
β (SE) = 0.012 (0.006) 70 to <80 16.94 1.05 (0.56-1.96) 1.22 19.07 20.99
χ2 (df) = 0.25 (2) 60 to <70 26.77 1.33 (0.74-2.42) 1.36 24.04 23.27
<60 47.77 1.66 (0.95-2.89) 1.74 34.62 34.35
5: CARTA FEV1/FVC 90+ (99.82) 1.00 1.00 3.72 7.84
β (SE) = 0.072 (0.049) 80 to <90 −0.99 3.87 (1.12-15.05) 0.93 5.83 2.95
χ2 (df) = 5.25 (1), p<0.05 <80 9.64 5.18 (1.56-19.66) 2.00 6.66 5.42
6: FINKEL FEV1%P 100+ (109.54) 1.00 1.00 7.75 6.71
β (SE) = 0.009 (0.011) 80 to <100 18.00 0.89 (0.39-2.18) 1.17 13.43 15.32
χ2 (df) = 0.47 (1) <80 41.17 1.35 (0.57-3.36) 1.44 11.17 10.31
9: LANGE FEV1%P 80+ (100.99) 1.00 1.00 47.92 48.77
β (SE) = 0.020 (0.004) 40 to <80 32.64 2.10 (1.30-3.40) 1.93 24.67 23.05
χ2 (df) = 0.17 (1) <40 69.50 3.90 (2.20-7.20) 4.05 13.46 14.23
11: MANNIN FEV1%P 80+ (100.24) 1.00 1.00 84.98 84.94
β (SE) = 0.022 (0.006) <80 33.97 2.12 (1.44-3.11) 2.12 35.83 35.87
12: MRFIT FEV1 unnormalised,ml ≥3674 (105.91) 1.00 1.00 27.01 26.50
β (SE) = 0.031 (0.005) 3307 to 3673 10.05 1.31 (0.82-2.10) 1.37 45.30 46.34
χ2 (df) = 0.85 (3) 2985 to 3306 15.92 1.50 (0.95-2.36) 1.64 54.20 58.27
2606 to 2984 22.21 2.13 (1.39-3.26) 2.00 80.62 74.45
≤2605 37.59 3.13 (2.07-4.72) 3.23 106.01 107.59
13: NOMURA FEV1%P 103.5+ (113.14) 1.00 1.00 22.16 23.76
β (SE) = 0.018 (0.005) 94.5 to <103.5 14.40 1.00 (0.60-1.90) 1.29 23.34 32.35
χ2 (df) = 11.40 (2), p<0.01 84.5 to <94.5 23.45 2.50 (1.50-4.10) 1.52 44.66 29.09
<84.5 43.11 2.10 (1.30-3.50) 2.15 49.51 54.48
14: PETO SDs of FEV1/h3 below average Above average (103.85) 1.00 1.00 32.15 39.80
β (SE) = 0.018 (0.008) 0 to 1 15.05 2.17 (1.40-3.38) 1.32 46.77 35.18
χ2 (df) = 6.81 (2), p<0.05 1 to 2 34.30 2.02 (0.97-3.90) 1.88 9.93 11.43
2+ 65.85 1.89 (0.37-5.90) 3.35 2.03 4.47
15: PURDUE FEV1%P 80+ (100.13) 1.00 1.00 1698.83 1698.83
β (SE) = 0.023 (0.002) <80 31.76 2.06 (1.77-2.39) 2.06 189.24 189.24
16: RENFREh FEV1%P Quintile 5 (116.04) 1.00 1.00 31.54 35.64
β (SE) = 0.015 (0.003) Quintile 4 13.70 1.36 (0.86-2.13) 1.22 42.34 42.97
χ2 (df) = 1.48 (3) Quintile 3 23.79 1.81 (1.18-2.78) 1.42 55.91 49.41
Quintile 2 35.19 1.93 (1.27-2.94) 1.67 62.88 61.57
Quintile 1 57.75 2.53 (1.69-3.79) 2.32 79.83 82.90
17: RENFREi FEV1%P Quintile 5 (119.96) 1.00 1.00 6.22 15.69
β (SE) = 0.011 (0.005) Quintile 4 13.53 3.63 (1.49-8.84) 1.15 21.19 16.98
χ2 (df) = 8.39 (3), p<0.05 Quintile 3 24.26 4.03 (1.68-9.67) 1.29 24.88 20.11
Quintile 2 36.19 4.12 (1.73-9.81) 1.47 27.21 24.40
Quintile 1 59.75 4.37 (1.84-10.42) 1.88 27.40 29.72
18: SKILLR FEV1%P 85+ (100.81) 1.00 1.00 1.99 1.99
β (SE) = 0.034 (0.017) < = 70 44.85 4.50 (0.99-20.37) 4.50 8.97 8.97
19: SPEIZEh Mean FEV1,ℓ.j 4.07 (109.98) 1.00 1.00 2.09 3.72
β (SE) = 0.048 (0.014) 3.54 9.02 4.33 (1.19-23.71) 1.54 9.35 5.93
χ2 (df) = 4.49 (2) 3.18 16.84 2.10 (0.45-12.96) 2.25 3.85 7.35
2.55 33.30 9.60 (2.93-49.67) 4.98 21.90 20.19
20: SPEIZEi Mean FEV1,ℓ.j 2.90 (112.16) 1.00 1.00 0.50 0.62
β (SE) = 0.054 (0.029) 2.57 10.10 3.17 (0.25-166.25) 1.73 1.36 0.92
χ2 (df) = 0.52 (2) 2.34 19.47 2.05 (0.11-121.19) 2.86 0.85 1.48
1.95 35.49 8.94 (1.20-396.75) 6.80 5.74 5.43
21: STAVEM Mean FEV1%P 121.90 (121.90) 1.00 1.00 8.99 6.19
β (SE) = 0.021 (0.008) 106.60 15.30 0.78 (0.29-2.07) 1.38 6.89 8.42
χ2 (df) = 4.48 (2) 95.30 26.60 0.67 (0.24-1.86) 1.76 6.00 10.86
75.70 46.20 2.23 (1.03-4.83) 2.67 20.40 16.82
24: TOCKMA FEV1%P >85 (102.90) 1.00 1.00 22.27 22.72
β (SE) = 0.021 (0.010) 60 to 85 27.52 2.57 (0.87-7.56) 1.78 3.82 2.70
χ2 (df) = 0.60 (1) <60 57.43 2.72 (0.76-9.74) 3.34 2.61 3.27
25: VANDENk FEV1 unnormalised, ℓ 3.85+ (105.38) 1.00 1.00 5.34 4.12
β (SE) = 0.018 (0.013) 3.35-3.85 7.12 1.19 (0.41-3.49) 1.14 8.82 6.47
χ2 (df) = 2.23 (3) 2.85-3.35 9.72 0.76 (0.27-2.14) 1.19 10.80 13.02
2.35-2.85 11.23 0.76 (0.27-2.14) 1.22 11.01 13.64
<2.35 31.46 1.49 (0.55-4.05) 1.75 13.75 12.46
26: VANDENl FEV1 unnormalised, ℓ 3.85+ (106.21) 1.00 1.00 6.84 10.05
β (SE) = 0.010 (0.007) 3.35-3.85 5.47 1.43 (0.60-3.42) 1.06 18.46 20.11
χ2 (df) = 1.63 (3) 2.85-3.35 10.13 1.76 (0.78-3.93) 1.11 41.81 38.92
2.35-2.85 14.67 1.80 (0.83-3.91) 1.17 81.93 78.13
<2.35 35.27 2.04 (0.92-4.54) 1.44 45.94 47.77
27: VANDENm FEV1 unnormalised, ℓ 3.85+ (104.52) 1.00 1.00 24.68 29.86
β (SE) = 0.012 (0.003) 3.35-3.85 9.72 1.32 (0.82-2.12) 1.12 55.20 56.66
χ2 (df) = 1.69 (3) 2.85-3.35 14.29 1.43 (0.94-2.19) 1.18 141.35 140.99
2.35-2.85 21.15 1.62 (1.08-2.44) 1.28 267.93 255.94
<2.35 40.79 1.89 (1.24-2.87) 1.61 167.40 173.12
28: VANDENn FEV1 unnormalised, ℓ 2.75+ (105.01) 1.00 1.00 7.50 5.82
β (SE) = −0.004 (0.016) 2.35-2.75 7.32 0.76 (0.30-1.90) 0.97 11.34 11.31
χ2 (df) = 2.92 (3) 2.05-2.35 8.70 0.60 (0.27-1.34) 0.97 29.24 36.34
1.65-2.05 8.73 0.92 (0.40-2.12) 0.97 21.57 17.51
<1.65 22.96 0.76 (0.33-1.78) 0.91 18.43 17.11
29: VANDENo FEV1 unnormalised, ℓ 2.35-2.75p (97.83) 1.00 1.00 11.85 9.95
β (SE) = 0.026 (0.011) 2.05-2.35 3.02 1.25 (0.61-2.57) 1.08 19.20 13.93
χ2 (df) = 6.55 (2), p<0.05 1.65-2.05 5.49 0.54 (0.24-1.21) 1.15 11.29 20.27
<1.65 27.83 1.92 (0.92-4.02) 2.05 17.24 15.43
30: VANDENq FEV1 unnormalised, ℓ 2.75+ (103.28) 1.00 1.00 9.63 21.54
β (SE) = 0.019 (0.004) 2.35-2.75 9.74 2.90 (1.46-5.77) 1.20 51.91 47.91
χ2 (df) = 8.13 (3), p<0.05 2.05-2.35 15.25 3.33 (1.72-6.48) 1.33 86.50 77.06
1.65-2.05 21.26 3.33 (1.74-6.37) 1.48 166.89 166.21
<1.65 41.80 4.76 (2.47-9.19) 2.17 107.33 109.53
31: WILES FEV1/h3, cl/m3 56+ (105.56) 1.00 1.00 23.36 25.12
β (SE) = 0.021 (0.008) 43-56 17.66 1.69 (0.97-2.94) 1.46 25.01 23.20
χ2 (df) = 1.02 (2) 30-43 36.24 2.65 (1.29-5.20) 2.17 11.02 9.68
0-30 70.93 2.87 (0.56-9.30) 4.54 1.97 3.34
32: WILSONg FEV1%P 80+ (100.14) 1.00 1.00 10.78 10.85
β (SE) = 0.008 (0.007) 50 to <80 30.94 1.30 (0.64-2.65) 1.28 22.87 22.73
χ2 (df) = 0.002 (1) <50 62.07 1.65 (0.70-3.90) 1.65 9.21 9.28
TOTALr FEV1%P (106.16) 388.51 431.45
χ2 (df) = 8.43 (5) 0.01-10 259.67 257.83
10.01-20 666.20 658.51
20.01-30 742.1 694.76
30.01-40 364.31 358.07
>40 542.36 562.52

a For each block, the block number and study reference code is shown. Also shown in columns 1 and 2 are the values of β, the fitted slope of the relationship of log RR to the estimated mean difference (see note d), and the SE of β, and also, for blocks with more than two levels, the results of the goodness-of-fit test.

b This is the measure the data were originally recorded in.

c The range of values of the measure for which results were available.

d The estimated mean difference of FEV1%P between the comparison level and the level of interest. Shown in brackets is the estimate of FEV1%P for the comparison level.

e These are pseudo-numbers of cases estimated using the method of Hamling et al.[16].

f FEV1/FVC ≥0.70.

g FEV1/FVC<0.70.

h Males.

i Females.

j RRs were given by quartiles of FEV1 residuals calculated from a prediction equation. Mean FEV1 levels for each quartile were used to derive the differences in FEV1%P.

k Male never smokers.

l Male former smokers.

m Male current smokers.

n Female never smokers.

o Female former smokers.

p There were no deaths in the highest quintile (2.75+ ℓ).

q Female current smokers.

r Total over all blocks with more than two levels.

Fry et al.

Fry et al. BMC Cancer 2012 12:498   doi:10.1186/1471-2407-12-498

Open Data