Open Access Highly Accessed Research article

Systematic review with meta-analysis of the epidemiological evidence relating FEV1 decline to lung cancer risk

John S Fry, Jan S Hamling and Peter N Lee*

Author Affiliations

P N Lee Statistics and Computing Ltd, Sutton, Surrey, United Kingdom

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BMC Cancer 2012, 12:498  doi:10.1186/1471-2407-12-498

Published: 27 October 2012

Additional files

Additional file 1:

Quality. DOC file which describes the components of the Newcastle-Ottawa study quality scoring system, shows the scores allocated to each study, and for some scores gives the reason the study scored as negative. Scores relate to eight items - 1: “representativeness of the exposed cohort”, 2: “selection of the non-exposed cohort”, 3: “ascertainment of exposure”, 4: “demonstration that the outcome of interest was not present at start of the study”, 5: “comparability of the cohorts on the basis of design or analysis”, 6: “assessment of outcome”, 7: “was follow-up long enough for outcomes to occur”, and 8: “adequacy of follow up of cohorts”. Apart from item 5, which is scored as 0, 1 or 2, each item is scored as 0 or 1, so the total possible score for a study is 9.

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Additional file 2:

Others. DOC file summarizes the results for the four studies which satisfied the inclusion/exclusion criteria but were later rejected as estimates of β could not be derived.

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Additional file 3:

Fit. DOC file giving, for each of the blocks considered in Table 4 that include more than two levels, a plot by decline in FEV1%P of the observed RRs (with 95% CIs) and the RRs fitted based on the value of β for that block. The fitted value of β and its SE are shown in the heading for the block.

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