Table 3

Interactions between apoE genotypes and selected demographic and lifestyle variables on GC risk
Variables Cases Controls Any e2 Cases Controls Any e4
OR (95% CI) OR (95% CI)
Gender
 Female, e3/e3 51 (34.69) 96 (65.31) 1* 51 (34.69) 96 (65.31) 1*
 Female, variant 8 (27.59) 21 (72.41) 0.58 (0.20 – 1.65) 12 (24.00) 38 (76.00) 0.55 (0.23 – 1.32)
 Male, e3/e3 57 (26.64) 157 (73.36) 0.48 (0.27 – 0.88) 57 (26.64) 157 (73.36) 0.49 (0.27 - 0.89)
 Male, variant 7 (12.96) 47 (87.04) 0.49 (0.11 – 2.18) 14 (26.92) 38 (73.08) 1.52 (0.44 – 5.27)
P value for interaction° 0.347 0.660
Age
 <60 years, e3/e3 25 (17.73) 116 (82.27) 1* 25 (17.73) 116 (82.27) 1*
 <60 years, variant 4 (12.50) 28 (87.50) 0.35 (0.07 – 1.68) 7 (21.21) 26 (78.79) 0.70 (0.18 – 2.66)
 ≥60 years, e3/e3 84 (38.01) 137 (61.99) 2.85 (1.53 – 5.28) 84 (38.01) 137 (61.99) 2.84 (1.54 - 5.26)
 ≥60 years, variant 11 (21.57) 40 (78.43) 1.24 (0.21 – 7.26) 20 (28.57) 50 (71.43) 0.97 (0.21 – 4.36)
P value for interaction 0.807 0.964
Alcohol drinking
 Never, e3/e3 45 (24.06) 142 (75.94) 1* 45 (24.06) 142 (75.94) 1*
 Never, variant 5 (12.50) 35 (87.50) 0.29 (0.08 – 1.04) 12 (18.18) 54 (81.82) 0.62 (0.28 – 1.37)
 Ever, e3/e3 64 (36.57) 111 (63.43) 1.59 (0.88 – 2.86) 64 (36.57) 111 (63.43) 1.46 (0.81 – 2.62)
 Ever, variant 10 (23.26) 33 (76.74) 1.78 (0.37 – 8.50) 15 (40.54) 22 (59.46) 1.28 (0.35 – 4.66)
P value for interaction 0.468 0.707
Smoking status
 Never, e3/e3 54 (29.03) 132 (70.97) 1* 54 (29.03) 132 (70.97) 1*
 Never, variant 8 (20.51) 31 (79.49) 0.48 (0.18 – 1.28) 13 (20.00) 52 (80.00) 0.53 (0.23 – 1.23)
 Ever, e3/e3 54 (31.40) 118 (68.60) 1.41 (0.80 – 2.50) 54 (31.40) 118 (68.60) 1.39 (0.79 – 2.45)
 Ever, variant 7 (16.28) 36 (83.72) 0.68 (0.15 – 2.98) 13 (36.11) 23 (63.89) 1.98 (0.59 – 6.73)
P value for interaction 0.609 0.271
Fruit and vegetables intake
 Low, e3/e3 28 (29.47) 67 (70.53) 1* 28 (29.47) 67 (70.53) 1*
 Low ,variant 2 (9.09) 20 (90.91) 0.14 (0.02 – 0.87) 9 (32.14) 19 (67.86) 0.84 (0.28 – 2.49)
 High, e3/e3 78 (31.08) 173 (68.92) 1.17 (0.61 – 2.23) 78 (31.08) 173 (68.92) 1.12 (0.59 – 2.13)
 High, variant 11 (19.30) 46 (80.70) 2.83 (0.38 – 21.05) 16 (22.86) 54 (77.14) 0.62 (0.16 – 2.37)
P value for interaction 0.309 0.487

† OR adjusted by age, gender, alcohol consumption (as continuous variable), packyears of smoking, grilled meat consumption and familiy history of gastric cancer.

* Reference category.

° By likelihood ratio test.

De Feo et al.

De Feo et al. BMC Cancer 2012 12:494   doi:10.1186/1471-2407-12-494

Open Data