Table 2 |
||||||
| Association between colorectal cancer and statin use among 309 cases and 294 control patients (unadjusted model) and 190 cases and 209 control patients in the adjusted model | ||||||
| Statin use | Unadjusted model | Adjusted model | ||||
| Cases (309) | Controls (294) | Basic OR* (95% CI) | Cases (194) | Controls (211) | Adjusted OR† (95% CI) | |
| P-value | P-value | |||||
| No use of statins | 284 | 250 | 1.0 (referent) | 154 | 145 | 1.0 (referent) |
| ≥1dispensed prescription at least 2 months pre-recruitment | 25 | 44 | 0.52 (0.31, 0.89) | 15 | 38 | 0.33 (0.15, 0.69) |
| 0.016 ** | 0.004** | |||||
| ≥1dispensed prescription at least 7 months pre-recruitment | 24 | 38 | 0.60 (0.35, 1.04) | 14 | 32 | 0.39 (0.18, 0.85) |
| 0.067 | 0.017** | |||||
| ≥2 dispensed prescriptions at least 2 months pre-recruitment | 24 | 38 | 0.60 (0.35, 1.03) | 14 | 32 | 0.42 (0.19, 0.92) |
| 0.064 | 0.030** | |||||
| ≥2 dispensed prescriptions at least 7 months pre-recruitment | 23 | 34 | 0.65 (0.37, 1.14) | 13 | 28 | 0.49 (0.22, 1.08) |
| 0.135 | 0.077 | |||||
* Adjusted for matching factors (age +/−1 year), sex and region of residence). OR = Odds ratio; CI = confidence interval.
† Adjusted for matching factors ((age +/−1 year), sex and region of residence), Family history of cancer, past medical history of cancer, past medical history of bowel disease, BMI, smoking, physical activity and regular NSAID intake.
** statistically significant at p < 0.05.
Lakha et al. BMC Cancer 2012 12:487 doi:10.1186/1471-2407-12-487
