Table 2

Association between colorectal cancer and statin use among 309 cases and 294 control patients (unadjusted model) and 190 cases and 209 control patients in the adjusted model
Statin use Unadjusted model Adjusted model
Cases (309) Controls (294) Basic OR* (95% CI) Cases (194) Controls (211) Adjusted OR† (95% CI)
P-value P-value
No use of statins 284 250 1.0 (referent) 154 145 1.0 (referent)
≥1dispensed prescription at least 2 months pre-recruitment 25 44 0.52 (0.31, 0.89) 15 38 0.33 (0.15, 0.69)
0.016 ** 0.004**
≥1dispensed prescription at least 7 months pre-recruitment 24 38 0.60 (0.35, 1.04) 14 32 0.39 (0.18, 0.85)
0.067 0.017**
≥2 dispensed prescriptions at least 2 months pre-recruitment 24 38 0.60 (0.35, 1.03) 14 32 0.42 (0.19, 0.92)
0.064 0.030**
≥2 dispensed prescriptions at least 7 months pre-recruitment 23 34 0.65 (0.37, 1.14) 13 28 0.49 (0.22, 1.08)
0.135 0.077

* Adjusted for matching factors (age +/−1 year), sex and region of residence). OR = Odds ratio; CI = confidence interval.

† Adjusted for matching factors ((age +/−1 year), sex and region of residence), Family history of cancer, past medical history of cancer, past medical history of bowel disease, BMI, smoking, physical activity and regular NSAID intake.

** statistically significant at p < 0.05.

Lakha et al.

Lakha et al. BMC Cancer 2012 12:487   doi:10.1186/1471-2407-12-487

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