Open Access Research article

Statin use and association with colorectal cancer survival and risk: case control study with prescription data linkage

Fatim Lakha1*, Evropi Theodoratou1, Susan M Farrington2, Albert Tenesa2, Roseanne Cetnarskyj3, Farhat V N Din2, Mary E Porteous4, Malcolm G Dunlop2 and Harry Campbell12

Author Affiliations

1 Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, UK

2 Colon Cancer Genetics Group, Western General Hospital, University of Edinburgh, Crewe Road, Edinburgh, UK

3 School of Nursing, Midwifery & Social Care, Faculty of Health, Life and Social Sciences, Edinburgh Napier University, Edinburgh, UK

4 South East Scotland Genetic Service, Western General Hospital, Edinburgh, UK

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BMC Cancer 2012, 12:487  doi:10.1186/1471-2407-12-487

Published: 22 October 2012

Additional files

Additional file 1:

Supplementary material 1. Annual prescribing of statins in Scotland, 2001-6. Supplementary material 2: Potential anti-tumour effects of statins as demonstrated by in-vitro studies. Supplementary material 3. Published cohort studies assessing the association between colorectal cancer and statin use. Supplementary material 4. Published case–control studies to date assessing the association between colorectal cancer and statin use. Supplementary material 5. Flow diagram of recruitment and participation. Supplementaty material 6. General description of AJCC. Supplementary material 7. Mechanism of data linkage via the Health Informatics Centre. Supplementary material 8. Distribution of cases across sex, age, and health board area of residence for participants, non-participants and withdrawn subjects. Supplementary material 9. Reason of no response for non-participants. Supplementary material 10. Distribution of controls across sex, age, health board area of residence and Carstairs deprivation index for participants, non-participants and withdrawn subjects. Supplementary material 11 Carstairs Deprivation Index criteria. Supplementary material 12. Characteristics of statin users versus non-users among control patients. Supplementary material 13. Characteristics of statin users versus non-users among female controls. Supplementary material 14. Characteristics of statin users versus non-users among male controls. Supplementary material 15 Association between statin use and use of sigmoidoscopy and/or colonoscopy. Supplementary material 16 Association between colorectal cancer and statin use among 211 cases and 194 control patients. Supplementary material 17. AJCC distribution according to statin use. Supplementary material 18. Published meta-analyses of RCTs investigating the association between colorectal cancer risk and statin use. Supplementary material 19. Published meta-analyses of observational studies investigating the association between colorectal cancer risk and statin use. Supplementary material 20. Post hoc power calculation. Supplementary material 21. Quantity of missing data for cases and controls.

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