Table 2

SF2, α and β values in spheres and their monolayer counterparts from established cervical cell lines

α (Gy-1)

β (Gy-2)

SF2

Cell line

Monolayer

Sphere

Monolayer

Sphere

Monolayer

Sphere


HeLa

0.166 ± 0.044

0.082 ±0.017

0.011 ± 0.006

0.013 ± 0.007

0.42 ± 0.06

0.60 ± 0.11

SiHa

0.099 ± 0.021

0.070 ± 0.011

0.013 ± 0.004

0.016 ± 0.005

0.56 ± 0.10

0.65 ± 0.09

Ca Ski

0.087 ± 0.032

0.032 ± 0.007

0.012 ± 0.000

0.013 ± 0.008

0.59 ± 0.04

0.76 ± 0.06

C-4 I

0.151 ± 0.075

0.115 ± 0.029

0.009 ± 0.003

0.011 ± 0.005

0.39 ± 0.05

0.53 ± 0.02


Parameters of cell survival curves were calculated using a linear-quadratic model for surviving fraction, SF. = exp (-αd - βd2). α: number of logs of cells killed per gray from the linear portion of the survival curve; β: number of logs of cells killed per gray2 from the quadratic component. Three independent experiments were performed.

López et al. BMC Cancer 2012 12:48   doi:10.1186/1471-2407-12-48

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