Table 1

In vivo tumorigenicity of cervical cancer-iniciating cells

Subpopulation

Cells

Tumors/injections


HeLa

SiHa

Ca Ski

C-4 I


1 × 103

2/6

3/6

0/6

0/6

Spheroid cells

1 × 104

4/6

4/6

3/6

2/6

1 × 105

5/6

4/6

4/6

4/6

1 × 105

0/6

0/6

0/6

0/6

5 × 105

1/6

1/6

0/6

0/6

1 × 106

5/6

2/6

0/6

0/6


Tumor formation ability of spheroids. Cells were grown in serum-free medium (SFM) as nonadherent cervospheres and assayed for the ability to form tumors after s.c. injection on nu-nu mice at 1 × 103, 1 × 104, and 1 × 105 cells per injection. At the same time, adherent cells were assayed at 1 × 105, 5 × 105, and 1 × 106 cells per injection. The number of tumors that formed and the number of injections performed are indicated for each condition

López et al. BMC Cancer 2012 12:48   doi:10.1186/1471-2407-12-48

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