Table 1

In vivo tumorigenicity of cervical cancer-iniciating cells

Subpopulation

Cells

Tumors/injections

HeLa

SiHa

Ca Ski

C-4 I

1 × 10³

2/6

3/6

0/6

0/6

Spheroid cells

1 × 10⁴

4/6

4/6

3/6

2/6

1 × 10⁵

5/6

4/6

4/6

4/6

1 × 10⁵

0/6

0/6

0/6

0/6

5 × 10⁵

1/6

1/6

0/6

0/6

1 × 10⁶

5/6

2/6

0/6

0/6

Tumor formation ability of spheroids. Cells were grown in serum-free medium (SFM) as nonadherent cervospheres and assayed for the ability to form tumors after s.c. injection on nu-nu mice at 1 × 10³, 1 × 10⁴, and 1 × 10⁵ cells per injection. At the same time, adherent cells were assayed at 1 × 10⁵, 5 × 10⁵, and 1 × 10⁶ cells per injection. The number of tumors that formed and the number of injections performed are indicated for each condition

López et al. BMC Cancer 2012 12:48   doi:10.1186/1471-2407-12-48