Open Access Highly Accessed Research article

Cancer-initiating cells derived from established cervical cell lines exhibit stem-cell markers and increased radioresistance

Jacqueline López1, Adela Poitevin2, Veverly Mendoza-Martínez4, Carlos Pérez-Plasencia3 and Alejandro García-Carrancá4*

Author Affiliations

1 Programa de Doctorado en Ciencias Bioquímicas, Facultad de Química, Universidad Nacional Autónoma de México, Mexico City, Mexico

2 Hospital Médica Sur, Unidad de Radioterapia, Mexico City, Mexico

3 Laboratorio de Oncología Genómica, Instituto Nacional de Cancerología & UBIMED-FESI, Universidad Nacional Autónoma de México, Mexico City, Mexico

4 Unidad de Investigación Biomédica en Cáncer, División de Investigación Básica, Instituto Nacional de Cancerología, Secretaría de Salud & Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City, Mexico

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BMC Cancer 2012, 12:48  doi:10.1186/1471-2407-12-48

Published: 28 January 2012

Additional files

Additional file 1:

Figure S1. Plating efficiency for monolayer- and spheroids-derived cells.

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Additional file 2:

Table S1- Genes. Selected group of genes whose expression was found up-or down-regulated by a factor of at least 1.5-fold in HeLa spheroid cells compared with HeLa monolayer cells.

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Additional file 3:

Table S2- Genes. Selected group of genes whose expression was found up-or down-regulated by a factor of at least 1.5-fold in SiHa spheroid cells compared with SiHa monolayer cells.

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Additional file 4:

Table S3- Genes. Biological functions of the genes with altered up-regulated expression by a factor of at least 1.5-fold in HeLa spheroid cells compared with HeLa monolayer cells, as determined by WebGestalt (Gene Set Analysis Toolkit).

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Additional file 5:

Table S4- Genes. Biological functions of the genes with altered down-regulated expression by a factor of at least 1.5-fold in HeLa spheroid cells compared with HeLa monolayer cells, as determined by WebGestalt (Gene Set Analysis Toolkit).

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Additional file 6:

Table S5- Genes. Biological functions of the genes with altered up-regulated expression by a factor of at least 1.5-fold in SiHa spheroid cells compared with SiHa monolayer cells, as determined by WebGestalt (Gene Set Analysis Toolkit).

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Additional file 7:

Table S6- Genes. Biological functions of the genes with altered down-regulated expression by a factor of at least 1.5-fold in SiHa spheroid cells compared with SiHa monolayer cells, as determined by WebGestalt (Gene Set Analysis Toolkit).

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Additional file 8:

Figure S2- Genes. Vein diagram for common genes between HeLa and SiHa spheroid cells compared with monolayer cells, whose expression was found up- and down-regulated by a factor of at least 1.5-fold.

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