Open Access Highly Accessed Research article

Tissue Tolerable Plasma (TTP) induces apoptosis in pancreatic cancer cells in vitro and in vivo

Lars Ivo Partecke1*, Katja Evert2, Jan Haugk1, Friderike Doering1, Lars Normann1, Stephan Diedrich1, Frank-Ulrich Weiss3, Matthias Evert2, Nils Olaf Huebner4, Cristin Guenther1, Claus Dieter Heidecke1, Axel Kramer4, René Bussiahn5, Klaus-Dieter Weltmann5, Onur Pati1, Claudia Bender4 and Wolfram von Bernstorff1

Author Affiliations

1 Department of General, Visceral, Thoracic and Vascular Surgery, University Medicine Greifswald, Ernst-Moritz-Arndt University, Greifswald, Germany

2 Institute of Pathology, University Medicine Greifswald, Ernst-Moritz-Arndt University, Greifswald, Germany

3 Department of Gastroenterology and Nephrology, University Medicine Greifswald, Ernst-Moritz-Arndt University, Greifswald, Germany

4 Institute of Hygiene and Environmental Medicine, University Medicine Greifswald, Ernst-Moritz-Arndt University, Greifswald, Germany

5 Leibniz Institute of Plasma Science and Technology (INP), Felix Hausdorff-Str. 2, Greifswald, Germany

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BMC Cancer 2012, 12:473  doi:10.1186/1471-2407-12-473

Published: 15 October 2012

Additional files

Additional file 1:

Table S1. The murine cell line 6606PDA and the human cell line PaTu8988T were treated with TTP using the same set up as for Colo-357 (Table 1). 6606PDA as well as PaTu8988T showed a significant increase in cell death after TTP treatment (p=0.0303 and p=0.0043, respectively).

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Additional file 2:

Figure S1. Cell cycle analyses: Percentage of apoptosis as sub-diploid peaks left to G0/G1-peak. Apoptotic cells 72 hours after TTP versus control and argon gas; example of 5 independent experiments.

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