Western blotting analysis of H3K27 methylation-modifying enzymes and H3K27me3 levels. The protein expression levels of the H3K27 demethylases UTX and JMJD3 were higher in RCC cancer tissues (C) than in paired adjacent normal tissues (A). The H3K27me3 level was lower in RCC cancer tissues, although the protein level of the H3K27 methyltransferase EZH2 was increased.
Shen et al. BMC Cancer 2012 12:470 doi:10.1186/1471-2407-12-470