Open Access Highly Accessed Research article

Vincristine enhances amoeboid-like motility via GEF-H1/RhoA/ROCK/Myosin light chain signaling in MKN45 cells

Masato Eitaki, Tohru Yamamori, Shunsuke Meike, Hironobu Yasui and Osamu Inanami*

Author Affiliations

Department of Environmental Veterinary Sciences, Laboratory of Radiation Biology, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, 060-0818, Japan

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BMC Cancer 2012, 12:469  doi:10.1186/1471-2407-12-469

Published: 12 October 2012

Additional files

Additional file 1:

Video S1. (.wmv, 3.94 MB). Time-lapse image sequence of control MKN45 cell in 3D Matrigel environment.

Format: WMV Size: 3.9MB Download file

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Additional file 2:

Video S2. (.wmv, 4.55 MB). Time-lapse image sequence of MKN45 cells treated with 15 µM vincristine in 3D Matrigel environment.

Format: WMV Size: 4.6MB Download file

Open Data

Additional file 3:

Video S3. (.wmv, 5.39 MB). Time-lapse image sequence of MKN45 cells treated with 15 µM vincristine in 3D Matrigel environment.

Format: WMV Size: 5.4MB Download file

Open Data