Table 2

Odds Ratios (ORs) and 95% Confidence Intervals (CIs) for the association between inflammatory variants and biliary stones, gallbladder and ampulla of Vater cancers in the Shanghai population
SNPs rs# Controls1n(%) Casesn(%) OR2 (95% CI) p3 FDR p4
    Biliary stones
VEGFA 9921bp 3' of STP A>G rs9367173
GG 539 (82.9) 837 (86.8) 1.0
AG 102 (15.7) 126 (13.1) 0.8 (0.60-1.07)
AA 9 (1.4) 6 (0.6) 0.4 (0.14-1.15)
trend3 0.03 0.2
AG+AA 111 (17.1) 132 (13.7) 0.77 (0.58-1.01)
VEGFA 6507bp 3' of STP G>A rs6905288
AA 357 (55.3) 499 (51.8) 1.0
AG 249 (38.5) 386 (40.0) 1.14 (0.92-1.41)
GG 40 (6.2) 81 (8.4) 1.5 (1.00-2.25)
trend3 0.04 0.2
AG+GG 289 (44.7) 467 (48.4) 1.19 (0.97-1.46)
    Gallbladder cancer
IL8 -13985C>G rs10805066
CC 647 (81.1) 187 (73.0) 1.0
CG 140 (17.5) 68 (26.6) 1.67 (1.20-2.34)
GG 11 (1.4) 1 (0.4)
trend3 0.03 0.2
CG+GG 151 (18.9) 69 (27.0) 1.57 (1.13-2.18)
    Ampulla of Vater Cancer
RNASEL IVS5+170G>A rs672527
GG 712 (83.6) 39 (73.6) 1.0
AG 133 (15.6) 11 (20.8) 1.54 (0.77-3.10)
AA 7 (0.8) 3 (5.7) 8.40 (2.06-34.14)
trend3 0.01 0.09
AG+AA 140 (16.4) 14 (26.4) 1.88 (0.99-3.57)
IL8 -13985C>G rs10805066
CC 685 (80.4) 37 (69.8) 1.0
CG 156 (18.3) 13 (24.5) 1.59 (0.82-3.07)
GG 11 (1.3) 3 (5.7) 5.6 (1.47-21.42)
trend3 0.02 0.1
CG+GG 167 (19.6) 16 (30.2) 1.83 (0.99-3.39)

1 Gallbladder cancer cases compared with population controls who had a gallbladder, Ampulla of Vater cancer cases compared with all population controls and Biliary stone cases compared with population controls who did not have biliary stones; 2 Adjusted for gender and age group; 3 Test of trend for genotype under additive model; 4 Adjusted by using the Benjamini-Hochberg method.

Castro et al.

Castro et al. BMC Cancer 2012 12:468   doi:10.1186/1471-2407-12-468

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