Open Access Highly Accessed Research article

Overexpression of CD44 accompanies acquired tamoxifen resistance in MCF7 cells and augments their sensitivity to the stromal factors, heregulin and hyaluronan

Stephen Hiscox1*, Bedanta Baruah4, Chris Smith1, Rebecca Bellerby2, Lindy Goddard1, Nicola Jordan1, Zaruhi Poghosyan3, Robert I Nicholson1, Peter Barrett-Lee4 and Julia Gee1

Author Affiliations

1 Welsh School of Pharmacy, Cardiff University, Wales, UK

2 School of Biosciences, Cardiff University, Wales, UK

3 School of Medicine, Cardiff University, Wales, UK

4 Academic Breast Unit, Velindre Cancer Centre, Wales, UK

For all author emails, please log on.

BMC Cancer 2012, 12:458  doi:10.1186/1471-2407-12-458

Published: 6 October 2012

Additional files

Additional file 1:

Figure S1. CD44v3 is associated with poor endocrine response. Immunohistochemical analysis of CD44v3 expression in clinical breast cancers revealed an association between high (>median H-score) CD44v3 and both a shortened duration of response and overall survival. (PPT 92 kb)

Format: PPT Size: 92KB Download file

This file can be viewed with: Microsoft PowerPoint Viewer

Open Data