Table 7

Change in EQ-5D healthstate index and EQ-5Doverall health rating byseverity of skin toxicity
Least-squares adjustedamean (95% CI)
WT KRAS (n= 76)b MT KRAS (n= 54)b Overall (n= 137)b
EQ-5D health state index
  Worst ST grade 0/1 0.03 (-0.10, 0.15) 0.01(-0.12, 0.14) 0.01 (-0.08, 0.09)
  Worst ST grade 2+ 0.04 (-0.01, 0.09) -0.02 (-0.11, 0.06) 0.00 (-0.05, 0.04)
  Difference -0.01 (-0.14, 0.12) 0.03 (-0.12, 0.19) 0.01 (-0.09, 0.10)
EQ-5D overall health rating
  Worst ST grade 0/1 -2.4 (-19.1, 14.4) -3.5 (-12.2, 5.2) -3.4 (-10.9, 4.2)
  Worst ST grade 2+ 4.2 (-2.5, 10.9) -6.1 (-12.0,-0.2) -1.8 (-5.9, 2.2)
  Difference -6.6 (-24.6, 11.5) 2.6 (-8.0, 13.2) -1.5 (-10.1, 7.1)

Data are presented as least-squares adjusted mean (95% CI) change in score from baseline through disease progression.

aMixed effect model including fixed effects of time, skin toxicity, baseline EQ-5D score, and the interaction between time and skin toxicity (ST). Interaction of ST with baseline EQ-5D score with P < 0.1 was also included in the final model, as were random effects for intercept and time; bTotal n shown; actual n number varies for each ST subgroup and scale.

Thaler et al.

Thaler et al. BMC Cancer 2012 12:438   doi:10.1186/1471-2407-12-438

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