Evidence for different mechanisms of ‘unhooking’ for melphalan and cisplatin-induced DNA interstrand cross-links in vitro and in clinical acquired resistant tumour samples
1 CR-UK Drug-DNA Interactions Research Group, UCL Cancer Institute, Paul O’Gorman Building, 72 Huntley Street, London, WC1E 6BT, UK
2 Centre for Clinical Haematology, Queen Elizabeth Hospital, Birmingham B15 2TH, UK
3 CR-UK/UCL Cancer Clinical Trials Centre, London, UK
BMC Cancer 2012, 12:436 doi:10.1186/1471-2407-12-436Published: 28 September 2012
Additional file 1:
Table S1. GI50 values (dose of drug that inhibits growth by 50%) for melphalan and cisplatin in the human A548, RPMI8226 cell lines. Drug exposure was for 1 hour at 37°C and cells were incubated in drug-free medium for a further 4 days prior to analysis using the sulforhodamine B assay. Values are mean±s.d. from at least three independent experiments.
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