Table 5

Analysis of interaction betweenpolymorphisms and worker inlist A occupation inlung cancer risk
Cases/Controls n(%)/n(%) pa Unadjusted Adjustedb p-interaction
OR [95% CI] OR [95% CI]
CYP1A1 * List Ac
T/T–No list A 494(62.6)/544(68.9) 0.006 Reference Reference 0.128
T/C+C/C–No list A 147(18.6)/141(17.9) 1.15 [0.88-1.49] 1.04 [0.77-1.39]
T/T–List A 114(14.4)/88(11.1) 1.43 [1.05-1.93] 1.15 [0.82-1.62]
T/C+C/C–List A 34(4.3)/16(2.0) 2.34 [2.27-4.30] 2.20 [1.11-4.35]
GSTM1 * List A
present/present–No list A 308(39.7)/317(40.8) 0.015 Reference Reference 0.700
>=1 null allele–No list A 322(41.5)/357(46.0) 0.93 [0.75-1.15] 0.97 [0.75-1.24]
present/present–List A 67(8.6)/41(5.3) 1.68 [1.10-2.56] 1.38 [0.86-2.22]
>=1 null allele–List A 79(10.2)/61(7.9) 1.33 [0.92-1.93] 1.18 [0.78-1.79]
GSTT1 * List A
present/present–No list A 501(64.6)/525(67.6) 0.015 Reference Reference 0.439
>=1 null allele–No list A 129(16.6)/149(19.2) 0.91 [0.70-1.18] 0.81 [0.60-1.09]
present/present–List A 117(15.1)/86(11.1) 1.43 [1.05-1.93] 1.21 [0.86-1.70]
>=1 null allele–List A 29(3.7)/16(2.1) 1.90 [1.02-3.55] 1.33 [0.67-2.64]
GSTP1 * List A
Ile/Ile–No list A 289(36.7)/289(36.7) 0.010 Reference Reference 0.815
Ile/Val+Val/Val–No list A 350(44.4)/396(50.2) 0.88 [0.71-1.10] 0.84 [0.66-1.08]
Ile/Ile–List A 63(8.0)/41(5.2) 1.54 [1.00-2.36] 1.38 [0.85-2.22]
Ile/Val+Val/Val–List A 86(10.9)/62(7.9) 1.39 [0.96-2.00] 1.08 [0.72-1.62]

a Chi-squared p-value.

b Adjusted by age, family history of any cancer, and pack-years (non-smoker, <37PY, ≥37PY).

c List A includes occupations known to be associated with lung cancer.

López-Cima et al.

López-Cima et al. BMC Cancer 2012 12:433   doi:10.1186/1471-2407-12-433

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