Open Access Research article

Prognostic significance of 5-fluorouracil metabolism-relating enzymes and enhanced chemosensitivity to 5-fluorouracil by 5-chloro 2,4-dihydroxy-pyridine in urothelial carcinoma

Hiroki Ide, Eiji Kikuchi*, Masanori Hasegawa, Norihide Kozakai, Takeo Kosaka, Akira Miyajima and Mototsugu Oya

Author Affiliations

Department of Urology, Keio University School of Medicine, Tokyo, Japan

For all author emails, please log on.

BMC Cancer 2012, 12:420  doi:10.1186/1471-2407-12-420

Published: 22 September 2012

Additional files

Additional file 1:

Cox regression analysis of progression-free anddisease-specific survival. LVI: lymphovascular invasion; TS: thymidylate synthase; DPD: dihydropyrimidine dehydrogenase; HR: hazard ratio; CI: confidence interval.

Format: DOC Size: 39KB Download file

This file can be viewed with: Microsoft Word Viewer

Open Data

Additional file 2:

Median and inter-quartile range of levels of TS and DPD and effect of CDHP on 5-FU cytotoxicity in UC cell lines. TS: thymidylate synthase; DPD: dihydropyrimidine dehydrogenase; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; CDHP: 5-chloro-2,4-dihydroxypyridine.

Format: DOC Size: 36KB Download file

This file can be viewed with: Microsoft Word Viewer

Open Data