Cytotoxic profiles of PLGem and GemPo on PANC1 cells. (A) PLGem’s and (B) GemPo’s effects on human pancreatic carcinoma cell proliferation were determined by MTS assay. PANC1 cells were plated on 96-well plates in the presence or absence of either (A) empty PLGA vehicle, free drug (Gemcitabine) and PLGem or (B) empty liposome vehicle, free Gemcitabine and GemPo, in a concentration-dependent manner. After three days, the proportion of live cells remaining were quantified and plotted as percentage of solvent-treated cells. Legend is indicated in inset. *p <; 0.05 between nanoparticle and free drug.
Papa et al. BMC Cancer 2012 12:419 doi:10.1186/1471-2407-12-419