Table 3

Comparison of Diagnostic Results of NAB alone and NAB combined with Tumor Markers in 194 Patients
Diagnostic Method Sensitivity (%) Specificity (%) Accuracy(%) PPV (%) NPV (%)
NAB alone 83.5 100.0 88.1 100.0 70.5
NAB+Serum Tumor marker
CYFRA (3.3) 85.6 81.8 84.5 92.2 69.2
CEA (5) 86.3 90.9 87.6 96.0 72.5
SCC (2) 84.2 92.7 86.6 96.7 69.9
NAB+Cytological Tumor marker
CYFRA (15.7) 95.0 98.2 95.9 99.2 88.5
CEA (0.6) 92.1 92.7 92.3 97.0 82.3
SCC (0.86) 91.4 70.9 85.6 88.8 76.5

Note-Numbers in parentheses are cut-off levels of tumor markers in ng/mL.

Abbreviations: PPV, positive predictive value; NPV, negative predictive value; CEA, carcinoembryonic antigen; SCC, squamous cell carcinoma; CYFRA, cytokeratin 19 fragments; NAB, needle aspiration biopsy.

Hur et al.

Hur et al. BMC Cancer 2012 12:392   doi:10.1186/1471-2407-12-392

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