Mean levels of circulating C-peptide, insulin and IGFBP-1 in adenoma cases and non-adenoma controls. C-peptide (p = 0.05) and insulin (p = 0.008) levels were significantly elevated in cases compared to controls. Mean plasma IGFBP-1 was lower in cases than in controls but the results did not reach statistical significance.
Vidal et al. BMC Cancer 2012 12:389 doi:10.1186/1471-2407-12-389