Table 2

Total and stratified analysis of ABCG2 C421A polymorphism on cancer risk
Variables AA versus CC AC versus CC A versus C Recessive model Dominant model
OR(95%CI) Pa OR(95%CI) Pa OR(95%CI) Pa OR(95%CI) Pa OR(95%CI) Pa
Total 1.021(0.730-1.428) 0.784 0.759(0.620-0.930)b 0.004 0.809(0.687-0.952)b 0.013 1.067(0.768-1.482) 0.935 0.771(0.634-0.938)b 0.005
Cancer type
colorectal cancer 1.073(0.491-2.344) 0.470 0.791(0.633-0.988) 0.445 0.840(0.688-1.025) 0.353 1.127(0.516-2.462) 0.494 0.806 (0.649-1.001) 0.388
lymphoma 1.200(0.736-1.958) 0.541 0.867(0.544-1.381) b 0.003 0.874(0.600-1.273) b 0.004 1.113 (0.692-1.791) 0.724 0.875(0.552-1.385) b 0.002
leukemia 1.371(0.507-3.704) 0.750 0.744(0.426-1.299) b 0.038 0.741(0.577-0.951) 0.072 1.474(0.543-4.002) 0.752 0.762(0.451-1.290) b 0.049
other 0.627(0.314-1.251) 0.419 0.574(0.407-0.808) 0.205 0.669(0.511-0.876) 0.827 0.822(0.420-1.607) 0.309 0.582 (0.420-0.807) 0.347
Source of control
Population based 0.684(0.383-1.223) 0.661 0.647(0.510-0.821) 0.289 0.710(0.582-0.867) 0.800 0.840(0.477-1.480) 0.594 0.654(0.520-0.823) 0.406
Hospital based 1.155(0.683-1.954) 0.897 0.721(0.627-0.829) 0.127 0.780(0.687-0.885) 0.158 1.225(0.724-2.075) 0.904 0.739(0.645-0.847) 0.133
HB + PB - - - -
Ethnicity
Asian 1.040(0.633-1.707) 0.143 0.856(0.287-2.549) b 0.000 0.923(0.478-1.784)b 0.002 1.069(0.666-1.715) 0.623 0.882(0.317-2.457) b 0.000
Caucasian 1.006(0.637-1.587) 0.846 0.723(0.638-0.820) 0.280 0.773( 0.690-0.866) 0.320 1.065(0.675-1.682) 0.849 0.737(0.652-0.833) 0.293

aP value of Q-test for heterogeneity test.

bRandom-effects model was used when P value for heterogeneity test <0.05; otherwise, fix-effects model was used.

Chen et al.

Chen et al. BMC Cancer 2012 12:383   doi:10.1186/1471-2407-12-383

Open Data