Proteasome inhibition effects on kinase levels in geldanamycin-treated cells. Relative quantification of kinases identified from Hs68 and SW480 cells treated with geldanamycin for 24 h with or without MG132 addition following enrichment on Kinobeads (from two independent experiments). Fold change refers to the ratio between geldanamycin + MG132-treated and geldanamycin-treated cells. Kinases are highly significantly increased (dark orange or blue) when fold change is > 1.2 and p-value < 0.01. FC - fold change.
Haupt et al. BMC Cancer 2012 12:38 doi:10.1186/1471-2407-12-38