TYMS mRNA expression is inversely related to the outcome of chemo-naïve 1st line treated patients who received taxanes and/or platinum containing schemes. Normal TYMS was not predictive of PFS upon any of these treatments. In comparison, aberrant TYMS was associated with favorable PFS in patients who did not receive taxanes (A) and in particular, in patients who received platinum containing chemotherapy without taxanes (B) or in combination with taxanes (C). In patients who received taxanes in any other combination except for platinum, aberrant TYMS was associated with poor PFS, as shown in A.
Kotoula et al. BMC Cancer 2012 12:342 doi:10.1186/1471-2407-12-342