Figure 1.

Methodology for identifying global transcription factor-interactome and important transcription factors in CRC. Depicts the overall methodology used to prioritize the TFs: (1) Data collection from peer reviews; (2) Discovery of associations using BioMAP (literature augmented data); (3) Validation of BioMAP associations using Gene Ontology distance and protein-protein interactions; (4) Construction of the global TF interaction network; (5) Ranking of TFs using multi-level, multi-parametric using: (i) weighted/un-weighted prioritization schema, (ii) hypergeometric associations, and (iii) Modules; and (6) Validation of TFs by pathway analysis.