Figure 2.

Overexpression of fascin leads to increase in cell migration, invasion and MMPs activity. (A and B) Phase contrast images (magnification 10×) of wound closure at 0 h, 6 h and 12 h of the vector control (AW-GFP-Cont) and fascin overexpressed clones (AW-Fascin-1 and AW-Fascin-2) are shown in the figure. Scale bar: 100 μm. The data shown is the average migration rate from three independent experiments with the mean and standard deviation (p < 0.05). (C) Boyden chamber invasion assay of vector control (AW-GFP-Cont) and fascin overexpressed clones (AW-Fascin-1 and AW-Fascin-2). The data shown is the average from three independent experiments with the mean and standard deviation (p < 0.01). (D) Zymogram showing MMP-2 activity in vector control (AWGFP-Cont) and fascin overexpressed (AW-Fascin-1 and AW-Fascin-2) cells.

Alam et al. BMC Cancer 2012 12:32   doi:10.1186/1471-2407-12-32
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